Promising research for celiacs

This exciting piece of news crossed my radar this morning: A paper from researchers at Stanford University outlines a possible path for treatment, and maybe even a cure, for celiac disease:

Rational Design of Combination Enzyme Therapy for Celiac Sprue

Here, we demonstrate that a two-enzyme cocktail comprised of a glutamine-specific cysteine protease (EP-B2) that functions under gastric conditions and a PEP, which acts in concert with pancreatic proteases under duodenal conditions, is a particularly potent candidate for celiac sprue therapy. At a gluten:EP-B2:PEP weight ratio of 75:3:1, grocery store gluten is fully detoxified within 10 min of simulated duodenal conditions, as judged by chromatographic analysis, biopsy-derived T cell proliferation assays, and a commercial antigluten antibody test.

This is preliminary research, but it holds much promise as described. All I want to do is not have to worry about ingesting a miniscule amount of gluten every time I eat; to turn the strict avoidance of gluten-containing foods into maybe a mere rule of thumb. To maybe enjoy a nice pint of hoppy pale ale again, on special occasions.

And then maybe we can work on that peanut/tree nut allergy thing some more. It seems that every one of us in this family, with the exception of Dylan, has some major allergies to live with. I suppose technically gluten intolerance isn’t considered an allergy, but there’s a fine line there. But the peanut/tree nut allergy is extremely frightening.

A cure for food allergies likely isn’t that far off. Current government funding levels are woefully inadequate, but it is generally felt that with proper financing these things could have viable treatment options within five to ten years.

One thought on “Promising research for celiacs”

  1. I don’t pretend to understand PEP weight ratios or duodenal conditions; if they allow people to overcome their food allergies, though, let those assays proliferate. Cheers!

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